The majority of Italian historical urban fabric is placed in earthquake prone areas. This study introduces the analysis of human behaviors in the earthquake risk assessment at urban scale: man-environment interactions in such conditions highly influence the inhabitants safety, especially in historical city centers. On these bases, this study proposes an agent-based earthquake evacuation simulator. Validation tests are performed on an Italian historical centre, demonstrating the validity of the model. Analysis on “human” behaviors should be combined to traditional evaluation in order to define integrated “risk maps” and “interventions maps”.