Within the postwar building stock, prefabricated buildings represent a significant subset in both terms of the quantity and the urgency of its safeguard, which is increasingly needed by their ongoing and extended deterioration phenomena. According to “The Twentieth-Century Historic Thematic Framework”, published in 2021 by Getty Conservation Institute, the heritage of prefabricated buildings is outlined in Theme 2, “Accelerated scientific and technological development”, enclosing the product of the large-scale pervasive effects of the technological progress of the 20th century. Nevertheless, at the time of this writing, the post-war industrialised buildings are still generally neglected and rarely protected: supported by the generalised public negative image of the prefabricated buildings – which have aged poorly – demolitions and the canceling of memories are broadly the case worldwide. In this text, some matters of fact and open issues functional to the reframing of industrialised buildings within the 20th-century architectural and technological heritage are outlined and discussed.